Naproxen: What It Is, How It Works, and What Alternatives You Should Know

When you reach for a pain reliever that lasts longer than ibuprofen, you might grab naproxen, a nonsteroidal anti-inflammatory drug used for pain, swelling, and fever. Also known as Aleve, it’s one of the most widely used NSAID options that doesn’t need a prescription in many countries.

Naproxen works by blocking enzymes that cause inflammation and pain—same as ibuprofen or aspirin—but it sticks around longer. That’s why one dose can last up to 12 hours, making it popular for arthritis, menstrual cramps, or back pain. But that long action also means it can build up in your system. If you’re on blood pressure meds, have kidney issues, or a history of stomach ulcers, naproxen can make things worse. It’s not the safest pick for everyone, even if it’s easy to buy off the shelf.

People often compare naproxen to ibuprofen—but they’re not the same. Ibuprofen kicks in faster, but naproxen lasts longer. If you need quick relief for a headache, ibuprofen wins. If you’re dealing with all-day joint pain, naproxen might be the better fit. Still, both carry similar risks: stomach bleeding, high blood pressure, and heart problems with long-term use. That’s why doctors often suggest trying acetaminophen first if your pain isn’t inflammatory. And if you’re already taking other meds—like blood thinners or SSRIs—naproxen can interact in ways you won’t see coming.

You’ll find posts here that dig into how naproxen stacks up against other painkillers like meloxicam and celecoxib. Some people swear by Mobic for arthritis, while others switch to naproxen after bad reactions to other NSAIDs. There’s also real talk about side effects—how often people get stomach burns, dizziness, or swelling—and what to do if you’ve been taking it daily for months. You’ll see comparisons with drugs like aceclofenac, which claims to be gentler on the gut, and learn why some patients stop naproxen cold after one bad experience.

This isn’t just another drug guide. These posts come from real users and clinicians who’ve seen what happens when people take naproxen without knowing the risks. You’ll find out who should never touch it, what symptoms mean trouble, and how to tell if your pain needs something stronger—or something safer.