Vilitra (Vardenafil) vs Other ED Meds: Detailed Comparison

Quick Take

• Vilitra works in 30‑45 minutes, lasts up to 5hours.
• Viagra (sildenafil) takes 30‑60 minutes, lasts about 4‑5hours.
• Cialis (tadalafil) needs 30‑120 minutes, but can stick around for 36hours.
• Stendra (avanafil) is the fastest, acting in 15‑30 minutes, lasting 4‑6hours.
• All share similar side‑effects; food‑fat mainly slows sildenafil and vardenafil.

Vilitra is a brand name for vardenafil, a PDE5 inhibitor used to treat erectile dysfunction (ED). It was approved by the FDA in 2003 and is available in 10mg and 20mg tablets for oral use. If you’re weighing it against other pills, you’ll want to look at four practical factors: how fast it kicks in, how long the effect lasts, how food and alcohol change the game, and what side‑effects you might feel.

How PDE5 Inhibitors Work

All the drugs we’ll compare belong to the PDE5 inhibitor class. They block the enzyme phosphodiesterase‑5, which normally breaks down cyclic guanosine monophosphate (cGMP). When cGMP stays around longer, smooth muscle in the penis relaxes, blood flows in, and an erection can happen in response to sexual stimulation.

Key Comparison Criteria

• Onset time: how quickly you feel the effect after swallowing.
• Duration of action: window during which sexual activity is possible.
• Food interaction: does a big meal slow you down?
• Dosage flexibility: can you fine‑tune the dose?
• Side‑effect profile: headache, flushing, visual changes, etc.
• Cost & insurance: typical price per tablet in the U.S. market (2025 data).

Side‑By‑Side Comparison Table

Deep Dive Into Each Alternative

Viagra (Sildenafil)

Viagra was the first oral ED drug to hit the market, making it the most recognizable name. It’s a good all‑rounder if you’re okay with a 30‑minute to one‑hour wait and don’t need a “weekend‑pill” effect. Food, especially something greasy, can push the onset out to 90minutes, so many users time it around a light snack.

Cialis (Tadalafil)

Cialis is the long‑acting champion. A 10mg dose can stay effective for up to 36hours, which is why it’s nicknamed the “apple‑of‑your‑eye” pill. It’s less sensitive to meals, making it handy for spontaneous plans. However, the longer half‑life brings a higher chance of lingering muscle aches for some men.

Stendra (Avanafil)

Stendra’s claim to fame is speed. Many men feel an effect within 15minutes, even after a big breakfast. The trade‑off is a slightly higher price tag and a shorter window of spontaneity compared with Cialis.

Levitra (Vardenafil - generic)

Levitra is essentially the same molecule as Vilitra but sold under a different label and often at a lower price. The performance profile mirrors Vilitra almost exactly, so the choice usually comes down to brand loyalty or insurance coverage.

Who Should Pick Vilitra?

If you want a middle‑ground option-faster than Viagra but not as long‑lasting (and pricey) as Cialis-Vilitra fits the bill. It’s also a solid pick when you’re comfortable planning a sexual encounter within a 4‑hour window and don’t mind a light snack beforehand. Men with mild to moderate cardiovascular risk can safely use it, provided they’re not on nitrates.

Safety, Contraindications, and Drug Interactions

All PDE5 inhibitors share a few red flags:

• Nitrate use: Combining with nitroglycerin (for chest pain) can cause a dangerous drop in blood pressure.
• Severe heart disease: Unstable angina, recent heart attack, or uncontrolled hypertension need a doctor’s clearance.
• Alcohol excess: Heavy drinking may worsen side‑effects like dizziness.
• Other meds: Certain antifungals, antibiotics, and HIV protease inhibitors can raise drug levels, requiring dose adjustments.

For Vilitra specifically, the recommended starting dose is 10mg; doctors may increase to 20mg or reduce to 5mg based on tolerability. It’s taken about an hour before sexual activity, and you shouldn’t exceed one tablet per 24hours.

Cost Considerations & Insurance

In 2025, generics drive the price down. A 30‑day supply of generic vardenafil (the same active ingredient as Vilitra) averages $30‑$45, while the brand version sits around $40‑$65. Insurance plans often favor the generic, so checking formularies can save you $15‑$25 per month.

Bottom Line Summary

Vilitra offers a reliable, mid‑range profile: quick enough for most planned dates, long enough to cover a night out, and affordable when you opt for the generic. Choose Viagra if you want a tried‑and‑true name and don’t mind a short meal‑delay. Go with Cialis when spontaneity over a whole weekend is a priority. Pick Stendra for the fastest kick‑off, and consider generic Levitra if cost is the main driver. Always talk to a healthcare professional before starting any ED medication, especially if you have heart conditions or take nitrate drugs.

Frequently Asked Questions

How fast does Vilitra work compared to Viagra?

Vilitra typically starts working in 30‑45 minutes, while Viagra can take 30‑60 minutes. The difference is small, but if you’re eating a high‑fat meal, Vilitra may feel a bit slower.

Can I take Viltria if I’m on blood pressure medication?

Most blood pressure drugs are safe with Vilitra, but you must avoid any medication that contains nitrates (like nitroglycerin). Always check with your pharmacist or doctor.

Is Vilitra safe for daily use?

The approved dosing is one tablet per day at most. Daily low‑dose regimens (like 5mg) are sometimes prescribed for men who want more spontaneity, but only under doctor supervision.

What are the most common side‑effects of Vilitra?

Headache, facial flushing, nasal congestion, and mild stomach upset are the top complaints. Severe side‑effects like sudden vision loss are rare but require immediate medical attention.

Does alcohol interfere with Vilitra?

A moderate amount of alcohol (one to two drinks) usually doesn’t affect the drug’s performance, but heavy drinking can increase dizziness and lower blood pressure, heightening side‑effects.